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Nhs health lottery

Nhs health lottery. The National Health Lottery is a commercial lottery game developed with the aim to contribute towards health-related good causes across Great Britain. Launched in 2011, tickets for this lottery first went on sale on Thursday 29t…

Tips to Lose Weight

Tips to Lose Weight. Tend not to Give up Weight Damage Objectives - Understand These tips! It doesn't matter how you take action, weight loss is usually an person factor. Buddies can assist you nonetheless they are unable to shed your excess weight …

Neem Uses and Benefits

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Neem Uses and Benefits. Neem desires not any introduction in today's world. A really well known natural herb regarding Of india having world-wide reputation and obtaining sensational components acknowledged due to the remarkable therapeutic values by previous 5000 many years. Neem is known as free of charge shrub regarding Of india mainly because it is located everywhere you go inside Of india. It can be considered as a miraculous shrub, containing components in which not simply eliminates but additionally treatments by illness. Neem shrub will be popularly known as margosa shrub inside The english language words and Azadirachta indica inside natural terms. It can be component of each and every Native indian residence automobile excellent program and as such is regarded as a place of worship. 
 
Margosa shrub attains a utmost top regarding 40 for you to 50 fts. It can be a great evergreen shrub in whose limbs multiply through out. This is a really densely crowned shrub, which might reach to some length regarding 35 for you to 40 fts. Your trunk will be fairly right. Bark will be thicker and abrasive having whitish for you to reddish colored brown leafy in look. Some sort of fluid termed neera excrudes out of your will often bark. Simply leaves are pinnate 12 for you to 15 inches long having concerning 20 for you to 31 environment friendly colored booklets, which might be concerning 3 to 5 cm long. Bouquets are small and white-colored inside colour in which floral inside spring i. elizabeth. January for you to walk. Some fruits are oblong in look environment friendly inside colour, when inside raw form and spins pale yellowish when the idea ripes. Each fresh fruit contains one particular seedling, that have acrylic. Neem shrub fruit inside summers i. elizabeth. inside May well for you to Come july 1st. Neem has been utilised while pesticide since first a long time because of its exceptional property or home regarding combating away having infestations and microorganism, which might be supposed to be unsafe regarding garden and homely function and as such creates neem probably the most fantastic companion regarding human inside his or her progress. 
 
Margosa tree possesses the sheet (cold) virya potency. It contains tickt and kashaya rasa, it possesses the laghu (light) gunna (property). Combination of these makes neem a unique herb. Due to tickt rasa it suppresses kapha and due to sheet virya potency it suppresses pitta dosha. Chemically neem contains complex compounds called triterpenes, limonoids, nonterpenoids, hexanortriterpenoids, and pentattriterpenoids. The most important active ingredient of neem is azadirachitin, which makes neem possess the power, what it projects in its usage. Every part of the plant is used i.e. flower, leaves, bark, seed, oil, branches and the excludant called neera, which flows out of the bark 
 
Neem is a multipurpose herb, which is recommended in every type of ailment. Following are the wonders of neem, which ayurveda has to offer to this world and modern life style of living. 
 
Local action: 
 
· Neem act as anti bacterial, anti parasitic, anti fungal, anti protozoal and anti viral thus helps in protection from all the microorganisms, which are always ready to invade in our body causing serious ailments. 
 
· Local application of neem powder or neem oil has miraculous results. As it is a famous anti microbial herb, it renders all the microorganisms inactive therefore helping in proper healing of wound without causing any infections and septic conditions. 
 
· Taking bath of neem leaves water is a very common sight in Indian homes that helps our body to counter mild infections, which our body might get in day-to-day activity. 
 
· Its tropical application makes us relieved from acne, eczema and even ringworms 
 
· In skin related diseases, neem works as blessing of God on mankind. It has an action on almost every kind of skin disease thus making its indication in eradicating every kind of itch, rash, infection and allergy. 
 
· Neem water is extensively used in burn injuries, thus to protect them from any kind of infection and also promote healing. 
 
· Neem oil is extensively used in hair fall and early graying of hairs with very satisfying results. It also find its application in dandruff and in lice growth 
 
· Its local application on arthritic conditions like rheumatoid arthritis, gout, Osteoarthritis, lower back pain, and musculo skeletal pains is highly recommended with good results 
 Internal action: 
 
· Due to presence of tickt rasa it is beneficial in indigestion, constipation and restoring taste of mouth. 
 
· It helps in fighting with the intestinal worms there by act as a deworming agent 
 
· It is highly recommended in hyperacidity and epigastric pain as it suppresses pitta that is the main culprit in the aggravation of such illness. 
 
· Good results have also been seen in gastritis 
 
· Widely and extensively used as blood purifier as it possess the properties like tickt rasa which helps in detoxifying any toxins floating in our blood stream which may lead to illness. 
 
· It gives wonderful results in diabetes incipidus and diabetes mellitus due to presence of tickt rasa. 
 
· It is very helpful in curing urinary tract infection 
 
· It stimulates liver for proper functioning therefore helps in maintaining proper secretions of liver 
 
· It acts on all kinds of skin disorders and provides great relief. 
 
· It works as an anti inflammatory and pain relieving agent 
 
· It also helps in suppressing extra heat generated in body due to any reason thus helps in maintaing normal condition in hyperthermia. Very useful in suppressing fever. 
 
· Anti malarial action of neem has also been seen 
 
· Since old times neem leaves have been used as an agent that helps in increasing vision as it helps in suppressing kapha disorders thus releasing congestion on eyeballs caused due to mucus accumulation in sinuses. 
 
· Coughing is relieved by use of neem water 
 
· It helps in reducing excess micturation 
 
· It has given very good results in diseases like gonorrhea and syphilis 
 
· It works as an immunoboosting agent therefore making our immune system very strong and efficient to fight against any foreign invasion making our body strong and disease free
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Neem Uses and Benefits. Neem desires not any introduction in today's world. A really well known natural herb regarding Of india having world-wide reputation and obtaining sensational components acknowledged due to the remarkable therapeutic values b…

Natural Techniques for Fair Complexion

Natural Tips. Natural Techniques for Fair Complexion. Couple of top notch masks to reduce skin develop as well as give a gleam towards skin. still care the skin is obviously vital that you sustain your skin and appearance refreshing continuously. Mi…

The risk of long-term use of the pill

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The risk of long-term use of the pill. Up to 43 percent of older adults use benzodiazepines (Valium, Xanax, Ativan, etc.) for anxiety and insomnia, often chronically, even though their long-term effectiveness and safety remain unproven. 
 
International guidelines recommend short-term use of benzodiazepines, because they cause withdrawal symptoms that make discontinuation problematic. Despite this, many seniors take them for years instead of a few weeks, as is recommended. 
 
But research has found another reason to avoid their long-term use, as new data suggests they're associated with the leading cause of dependency in older people… dementia, including Alzheimer's disease. 
 
Use of Benzodiazepines for Three Months or More Linked to Alzheimer's 
 
Older adults who used benzodiazepines for three months or more had a 51 percent greater risk of Alzheimer's disease than those who did not.2 The risks increased the longer the drugs were used, as well as with long-acting formulations. 
 
It's been suggested that the drugs might be linked to dementia because anxiety or sleeping issues may be early indicators of Alzheimer's. However, this study accounted for earlier diagnosis of those conditions, and an independent link between long-term benzodiazepine use and Alzheimer's still emerged. The researchers concluded: 
 
"Benzodiazepine use is associated with an increased risk of Alzheimer's disease. The stronger association observed for long term exposures reinforces the suspicion of a possible direct association, even if benzodiazepine use might also be an early marker of a condition associated with an increased risk of dementia. Unwarranted long term use of these drugs should be considered as a public health concern." 
 
    The findings echo at least four previous studies: 
 
A 2012 study found that among adults over 65, those who used benzodiazepines were 50 percent more likely to develop dementia over a 15-year This was true even when taking into account other factors that might increase dementia risk, such as age, gender, and diabetes. 
A 2009 study that found long-term use of benzodiazepines was significantly associated with an increased risk of dementia, leading researchers to recommend "long-term use of BZDs should be avoided among the elderly, who may be at a higher risk for developing dementia, in addition to other health problems." 
A 2005 literature review, which found three of six papers reviewed found an increased risk of cognitive decline in benzodiazepine users. 
A 2002 study that also found former use of benzodiazepines was associated with a significantly increased risk of dementia. 
 Sleeping Pills Also Raise Your Risk of Premature Death and Cancer 
 
Benzodiazepines have long been linked to an increased risk of motor vehicle accidents, which isn't surprising since common side effects include dizziness, unsteady gait and falling. They're also known to cause hip fractures, impairment of thinking and memory loss. However, one of the most disturbing "side effects" is an early death… 
 
Research involving data from more than 10,500 people who received drugs for poor sleep (including benzodiazepines) showed that "as predicted, patients prescribed any hypnotic had substantially elevated hazards of dying compared to those prescribed no hypnotics," and the association held true even when patients with poor health were taken into account -- and even if the patients took fewer than 18 pills in a year. 
 
The study suggested that those who take such medications are not only at higher risk for certain cancers, but are nearly four times more likely to die than people who don't take them. In The Dark Side of Sleeping Pills, an e-book by one of the study's researchers, Daniel Kripke, MD, it's explained: 
 
"We have now published a new study of over 10,000 patients who took sleeping pills and over 20,000 matched patients who did not take sleeping pills. The patients who took sleeping pills died 4.6 times as often during follow-ups averaging 2.5 years. 
 
Patients who took higher doses (averaging over 132 pills per year) died 5.3 times as often. Even those patients who took fewer than 18 pills per year had very significantly elevated mortality, 3.6 times that of patients who took no hypnotics. 
 
It seems quite likely that the sleeping pills were causing early death for many of the patients. In addition, those who averaged over 132 sleeping pills per year were 35% more likely to develop a new cancer… 
 
Theoretically, there could be confounding factors or biases in the selection of patients which caused these deaths without involving sleeping pills. We can only say that we found almost no evidence of such biases. …If sleeping pills cause even a small portion of the excess deaths and cancers associated with their use, they are too dangerous to use." 
 
Addiction Is a Very Real Problem with Benzodiazepines 
 
Benzodiazepines exert a calming effect by boosting the action of a neurotransmitter called gamma-aminobutyric acid (GABA) in the same way that opioids (heroin) and cannabinoids (cannabis) do. This in turn activates the gratification hormone, dopamine, in your brain. 
Since the identical brain "reward pathways" are used by both types of drugs, they can be equally addictive and also may cause side effects like memory loss, hip fractures, impaired thinking, and dizziness. 
 
Ironically, the symptoms of withdrawal from many of these anxiety medications include extreme states of anxiety – some of which are far worse than the original symptoms that justified treatment in the first place. Symptoms that may occur with benzodiazepine withdrawal include: 
 
Further, older adults, who make up a large proportion of the dependent population, have a much more difficult time eliminating benzodiazepines and similar drugs from their bloodstreams, especially while on multiple medications, which overburden their detoxification systems. Over time, these drugs can accumulate in your body, which will increase your risk of an accidental overdose. As reported in Current Opinions in Psychiatry: 
 
"Despite repeated recommendations to limit benzodiazepines to short-term use (2–4 weeks), doctors worldwide are still prescribing them for months or years. This over prescribing has resulted in large populations of long-term users who have become dependent on benzodiazepines and has also led to leakage of benzodiazepines into the illicit drug market… 
 
Recent literature shows that benzodiazepines have all the characteristics of drugs of dependence and that they are inappropriately prescribed for many patients…" 
 
    Optimizing Your Gut Flora 
 
Your gut and brain actually work in tandem, each influencing the other. This is why your intestinal health can have such a profound influence on your mental health, and vice versa; as well as the reason why your diet is so closely linked to your mental health. Prior research has shown that the probiotic Lactobacillus rhamnosus had a marked effect on GABA levels in certain brain regions and lowered the stress-induced hormone corticosterone, resulting in reduced anxiety- and depression-related behavior. 
 
So optimizing your gut flora with beneficial bacteria is a highly useful strategy. This is done by eliminating sugars and processed foods and eating plenty of non-starchy vegetables, avoiding processed vegetable oils, and using healthy fats. Additionally, eating plenty of fermented vegetables or taking a high-potency probiotic supplement would be useful to reestablish a healthy gut flora. 
     Omega-3 Fats 
 
Your diet should include a high-quality source of animal-based omega-3 fats, like krill oil. The omega-3 fats EPA and DHA play an important role in your emotional well-being, and research has shown a dramatic 20 percent reduction in anxiety among med students taking omega-3s. 
 
If Sleep Troubles Have Got You Down… 
 
I suggest reading my Guide to a Good Night's Sleep for 33 simple tips on improving your sleep before even considering sleeping pills. Small adjustments to your daily routine and sleeping area can go a long way to ensure uninterrupted, restful sleep (which may further help with anxiety symptoms, as well). To start, consider implementing the following changes. Number one on my list? Turn off your electronic gadgets and keep them out of your bedroom: 
 
<ul>
<li>Avoid watching TV or using your computer/smartphone or tablet in the evening, at least an hour or so before going to bed.</li>
<li>Make sure you get BRIGHT sun exposure regularly. Your pineal gland produces melatonin roughly in approximation to the contrast of bright sun exposure in the day and complete darkness at night. If you are in darkness all day long, it can't appreciate the difference and will not optimize your melatonin production.</li>
<li>Get some sun in the morning. Your circadian system needs bright light to reset itself. Ten to 15 minutes of morning sunlight will send a strong message to your internal clock that day has arrived, making it less likely to be confused by weaker light signals during the night.</li>
<li>Sleep in complete darkness, or as close to it as possible. Even the tiniest glow from your clock radio could be interfering with your sleep, so cover your clock radio up at night or get rid of it altogether. Move all electrical devices at least three feet away from your bed. You may want to cover your windows with drapes or blackout shades, or wear an eye mask when you sleep.</li>
<li>Install a low-wattage yellow, orange, or red light bulb if you need a source of light for navigation at night. Light in these bandwidths does not shut down melatonin production in the way that white and blue bandwidth light does. Salt lamps are handy for this purpose.</li>
<li>Keep the temperature in your bedroom no higher than 70°F. Many people keep their homes too warm (particularly their upstairs bedrooms). Studies show that the optimal room temperature for sleep is between 60 to 68°F.</li>
<li>Take a hot bath 90 to 120 minutes before bedtime. This increases your core body temperature, and when you get out of the bath it abruptly drops, signaling your body that you are ready to sleep.</li>
<li>Avoid using loud alarm clocks. Being jolted awake each morning can be very stressful. If you are regularly getting enough sleep, you might not even need an alarm, as you'll wake up naturally.</li>
<li>Be mindful of electromagnetic fields (EMFs) in your bedroom. EMFs can disrupt your pineal gland and its melatonin production, and may have other negative biological effects as well. A gauss meter is required if you want to measure EMF levels in various areas of your home. If possible, install a kill switch to turn off all electricity to your bedroom. If you need a clock, use a battery-operated one.</li>
<li>Both anxiety and sleep troubles are serious issues that need attention. Unfortunately, most people who suffer from these conditions either do nothing or resort to pharmaceutical drugs – many of which are ineffective and capable of destroying your health and sanity further. On the contrary, you have nothing to lose, and everything to gain, by applying the previously mentioned lifestyle modifications, and you may be surprised by how much they boost your mood and ability to sleep soundly, naturally.</li>
</ul>
 
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The risk of long-term use of the pill. Up to 43 percent of older adults use benzodiazepines (Valium, Xanax, Ativan, etc.) for anxiety and insomnia, often chronically, even though their long-term effectiveness and safety remain unproven. Internationa…

Are A person Producing Health and fitness Options Depending on Exactly what This kind of Business Top Party Affirms?

By Dr. Mercola 
 
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There are many dozens of industry front groups masquerading as independent information organizations. I've previously published information about several of them, including the International Food Additives Council (IFAC), the Coalition Against Costly Food Labeling Proposition, the Science Media Centre, and Alliance to Feed the Future. 
 
Michele Simon, JD, MPH, policy consultant with Center for Food Safety has also published a report titled: "Best Public Relations Money Can Buy: A Guide to Food Industry Front Groups,"1 which reveals how the food and agricultural industry hide behind friendly-sounding organizations aimed at fooling the public, policymakers, and the media. 
 
Institute for Science in Medicine2 is yet another example worth mentioning. Once you start to look at them more closely, you’ll find that most of these repetitive front groups “in the name of science” lead back to the same people... and the industry science they espouse is very much like a new religion—one that does not tolerate others beliefs. 
 
Here, the focus will rest on the American Council on Science and Health (ACSH). A previous Mother Jones3 article spilled the beans on who's actually funding this pro-industry science group, which defends everything from fracking to pesticides, the toxic plastic ingredient bisphenol-A (BPA), and genetically engineered foods—all in the name of quenching unwarranted fear mongering by those who don't understand the science. 
 
The ACSH claims to be an independent research and advocacy organization consisting of "concerned scientists" who are devoted to debunking "junk science." But once you understand who this front group really serves, it becomes easy to see why the scientific basis for the ACSH's recommendations may be questionable at best. As reported by the featured article: 
<blockquote class="tr_bq">
 
 "Internal financial documents... show that ACSH depends heavily on funding from corporations that have a financial stake in the scientific debates it aims to shape...</blockquote>
 
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According to the ACSH documents, from July 1, 2012, to December 20, 2012, 58 percent of donations to the council came from corporations and large private foundations. ACSH's donors and the potential backers the group has been targeting comprise a who's-who of energy, agriculture, cosmetics, food, soda, chemical, pharmaceutical, and tobacco corporations."</blockquote>
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By Dr. Mercola There are many dozens of industry front groups masquerading as independent information organizations. I've previously published information about several of them, including the International Food Additives Council (IFAC), the Coalitio…

Can Water Go Bad?

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Water is essential for life, and we typically assume that water is "clean" or "good" provided you're not getting your water from a contaminated source. But can water ever "go bad"? 
 
If you have a water filtration system in your home, it may not occur to you that your water could become contaminated after a while—until you go to clean out the holding tank, that is. 
 
If you fail to regularly clean out the holding tank of a reverse osmosis filter, it could lead to an absolute mess of microbial growth that is certainly NOT going to produce clean, pure water when you turn on the tap. 
 
<blockquote class="tr_bq">
And, as noted by Dr. Kellogg Schwab, director of the Johns Hopkins University Water Institute in a recent Time article, factors such as ambient temperature and exposure to sunlight and/or your lips can introduce microorganisms into your water glass or bottle, if left out for extended periods of time, which can then begin to thrive under the right conditions.</blockquote>
 
Reusing disposable plastic water bottles also has its risks, as discussed in the featured Huffington Post article. In short, water could "go bad" if you store it improperly, reuse dirty bottles, or fail to regularly clean your water filtration system. 
            
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Water is essential for life, and we typically assume that water is "clean" or "good" provided you're not getting your water from a contaminated source. But can water ever "go bad"? If you have a water filtration system in your home, it may not occur…

Sleep disorders Can lead to Mental faculties Shrinking.

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<tr><td class="tr-caption" style="text-align: center;">Brain health.</td></tr>
</tbody></table>
By Dr. Mercola 
 
    Recent studies show poor sleeping habits cause both brain damage and brain shrinkage, and may even accelerate onset of Alzheimer’s disease. 
 
    Previous research published in the journal Science revealed that your brain removes toxic waste during sleep through what has been dubbed “the glymphatic system.” 
 
    This system becomes active during sleep, thereby allowing your brain to clear out toxins and harmful proteins. 
 
    Sleep is also necessary for maintaining metabolic homeostasis in your brain. Without sufficient sleep, your neurons will actually begin to deteriorate—and catching up on sleep during weekends will not prevent this damage. 
 
    Lack of sleep has also been linked to obesity in both animals and humans, as well as hormone alterations in animals. In short, sleeping soundly appears to be key for aging well, and maintaining healthy brain function into old age. 
 
 Exposure to bright daylight serves as the major synchronizer of your master clock—a group of cells in your brain called the suprachiasmatic nuclei (SCN). These nuclei synchronize to the light-dark cycle of your environment when light enters your eye. 
 
You also have other biological clocks throughout your body, and those clocks subsequently synchronize to your master clock. One reason why so many people get so little sleep, and/or such poor sleep, can be traced back to a master clock disruption. 
 
In short, most people spend their days indoors, shielded from bright daylight, and then spend their evenings in too-bright artificial light. As a result, their body clocks get out of sync with the natural rhythm of daylight and nighttime darkness. 
 
This, it turns out, may have more far-reaching ramifications than previously thought, and humans are not the only ones affected by artificial lighting brightening up the night. 
 
For example, researchers investigating incidences of birds singing in the middle of the night believe that bird behavior is being adversely affected by artificial lighting from street lamps and city lights. 
 
Artificial Light Disrupts Sex Hormones in Birds 
 
    Mounting evidence suggests that artificial lights are actually “altering the basic physiology of urban birds, suppressing their estrogen and testosterone and changing their singing, mating and feeding behaviors,” Environmental Health News reports. 
 
    One animal study found that chronic exposure to light at night prevented reproductive organ development in male blackbirds. Their sex organs developed naturally during the first year, but in the second year of nighttime light exposure, the development stopped altogether. 
 
    Birds aren’t the only species suffering from light pollution. As noted in the featured article: 
<blockquote class="tr_bq">
    “In the wild, light pollution causes hatchling sea turtles to lose their way from beach to the ocean, and disorients Monarch butterflies searching for migration routes. 
 
    In field experiments, Atlantic salmon swim at odd times, and frogs stop mating under skies glowing from stadium lights at football games. Millions of birds die from collisions with brightly lit communication towers, and migratory flocks are confused by signals gone awry. 
 
    More recently, researchers have documented an earlier dawn chorus, which influences mate selection, feeding and interplay among species. At a deeper, molecular level, the changes in birds’ hormones raise questions about their reproductive fitness and the potential for ecological and evolutionary consequences.”</blockquote>
 
The researchers call for collaboration between scientists and policy makers to limit the impact of light pollution on animals and ecosystems. It’s easy to make the case that humans need to limit light pollution as well, in order to thrive... 
 
Future Obesity and Diabetes Treatments May Address Body Clock 
 
    If you’re overweight and/or exhausted much of the time, chances are high that poor sleep patterns 
perhaps resulting from too many light-emitting gadgets—are at play. The exposure to excessive amounts of light at night, courtesy of electric light bulbs and electronic gadgets of all kinds, makes it exceedingly difficult for your body and brain to wind down for sleep. And this lack of sleep can lead to metabolic dysfunction. Poor sleep has actually been implicated in obesity in a number of previous studies. 
 
    Most recently, scientists at the University of Manchester concluded that your body clock plays an important role in chronic inflammation and the accumulation of body fat. According to the University, the team’s findings “are helping develop new ways of treating obesity and the fatal diseases linked to being overweight.” According to lead researcher Professor David Ray: 
 
        “Essentially we discovered that the circadian clock protein REVERB plays an important role in the safe accumulation of body fat. Usually as fat accumulates there is inflammation in the body which leads to diabetes and heart disease. Our research shows that this process is linked to the body clock.” 
 
    The protein REVERB, which is linked to your body clock, not only regulates adinopectin—a hormone produced in body fat—but it’s also a master regulator of inflammation. They discovered that mice lacking this REVERB protein were able to accumulate more fat without the associated inflammation. According to Professor Ray: 
 
        “Our work demonstrates that it could be possible to switch unhealthy fat to a healthier form by tapping into one of the elements which we discovered. We hope that would mean fewer obese people go on to develop more severe metabolic complications such as type 2 diabetes and heart disease... Our analysis showed that in morbidly obese people who have undergone weight loss surgery the same pathway from the body clock to inflamed fat is activated.” 
 
    While they’re naturally looking for a drug solution to target this pathway, it would make sense to tap into it naturally by optimizing your body clock... There’s actually a clinical study underway at the University of Manchester in which they’re testing “body clock logic” to treat diabetes. According to the University: 
 
        “Patients eat, sleep and take medication at times that fit with their body clock in a bid to control the disease. It’s hoped the study will demonstrate that strengthening our internal body clock by changing behavior can be used to treat a condition in a similar way to drugs and surgery.” 
 Sleeping Pills Can Have Serious Consequences 
 
    According to the statistics from the Centers for Disease Control and Prevention (CDC), between 50 and 70 million Americans suffer from sleep deprivation, and nearly nine million Americans take prescription sleeping pills in pursuit of good night’s rest; one in six adults with a diagnosed sleep disorder and one in eight adults with trouble sleeping report using sleeping pills. In 2011, sales of generic Ambien (zolpidem tartrate) amounted to a whopping $2.8 billion and Lunesta another $912 million. 
 
    While most would not knowingly put their life on the line, you may be doing just that if you take sleeping pills... According to a study by the Substance Abuse and Mental Health Services Administration (SAMHSA), emergency room visits involving the sleep aid zolpidem nearly doubled between 2005 and 2010, reaching 42,274 visits in the year 2009-2010. Zolpidem is the active ingredient in sleep aids sold under brand names like Ambien, Ambien CR, Edluar, and Zolpimist. Polypharmacy—the use of multiple drugs—is part of the problem. In 57 percent of these overmedication cases, there were additional drugs involved: 
 
<blockquote class="tr_bq">
        In 26 percent of cases, zolpidem was combined with benzodiazepines (Valium, Xanax, Ativan, etc.) 
        25 percent involved a combination with narcotic pain relievers 
        Alcohol was also used in 14 percent of these emergency room visits</blockquote>
 
    Side effects associated with zolpidem include daytime drowsiness, dizziness, hallucinations, agitation, sleep-walking, and drowsiness while driving. It’s important to realize that narcotic pain relievers and anti-anxiety drugs or sedatives can cause a dangerous enhancement of a sleeping pill’s sedative effects. As noted by SAMHSA: 
 
        “Overall, nearly half (47 percent) of zolpidem overmedication-related emergency department visits resulted in either a hospital admission or a transfer to another medical facility. About a quarter of these more serious cases involved admission to a critical or intensive care unit. ‘Sleep aid medications can benefit patients, but they must be carefully used and monitored,’ said SAMHSA Administrator Pamela S. Hyde. ‘Physicians and patients need to discuss the potential adverse reactions associated with any medication, and work together to prevent problems or quickly resolve any that may arise.’” 
 
    Studies submitted to the FDA have also revealed that blood levels of zolpidem above 50 ng/mL may impair your driving to a degree that increases the risk of an accident, especially among women. As a result, FDA recommended manufacturers cut the dosage of zolpidem from 10mg to 5mg for immediate-release products (Ambien, Edluar, and Zolpimist) and from 12.5 mg to 6.25 mg for extended-release products (Ambien CR).21 Sleeping pills have also been linked to a 35 percent increased cancer risk, along with a greatly increased risk of death from any cause. 
 
Grave Risks for Drugs That Do Not Work... 
 
    These are serious risks for drugs that have repeatedly been shown to have little real-life value in terms of actually providing more or better sleep. An analysis of studies financed by the National Institutes of Health (NIH) found that sleeping pills like Ambien, Lunesta, and Sonata reduced the average time it takes you to go to sleep by just under 13 minutes compared with placebo, and increasing total sleep time by just over 11 minutes. However, the participants believed they had slept longer—up to an hour longer—when taking the pills. 
 
    This is thought to be due to a condition called anterograde amnesia, which prevents the proper formation of memories. When people wake up after taking sleeping pills, they may, in fact, simply forget that they’d been unable to sleep! Not surprisingly, sleeping pills are also associated with cognitive deficits the next day. Many sleeping pills are also potent anti-cholinergics, which suppress REM sleep and dreaming, and are known to increase dementia risk in seniors. 
 Helpful Tips to Improve Your Sleep 
 
    To get good sleep, you need to have properly aligned circadian rhythms, and to achieve that, you need to get daylight exposure, ideally around solar noon, for at least 30-60 minutes or more each day. Then, in the evening, you need to dim artificial light sources. In particular, you want to avoid the blue light wavelength. Research shows that exposure to bright room light before bedtime suppresses melatonin production in 99 percent of individuals. This can effectively rob you of sleep by preventing sleepiness. 
 
    Use blue-blocking light bulbs, dim your lights with dimmer switches and turn off unneeded lights, and if using a computer, install blue light-blocking software like f.lux. Also keep in mind that digital alarm clocks with blue light displays could have a detrimental effect. The following infographic, created by BigBrandBeds.co.uk, illustrates how your electronic gadgets wreak havoc on your sleep when used before bedtime. 
 
 To optimize sleep, you also need to make sure you’re going to bed early enough, because if you have to get up at 6:30am, you’re just not going to get enough sleep if you go to bed after midnight. Fitness trackers such as the UP can track both daytime body movement and sleep, allowing you to get a better picture of how much sleep you’re actually getting. Chances are, you’re getting at least 30 minutes less sleep than you think, as most people do not fall asleep as soon as their head hits the pillow. Besides maintaining a natural circadian rhythm, there are a number of additional ways to help improve your sleep if you’re still having trouble. Below are half a dozen of my top guidelines for promoting good sleep. For a comprehensive sleep guide, please see my article 33 Secrets to a Good Night's Sleep. 
 
    Avoid watching TV or using your computer at night—or at least about an hour or so before going to bed. TV and computer screens emit blue light, similar to daylight. This tricks your brain into thinking it's still daytime, thereby shutting down melatonin secretion. 
    Sleep in darkness. You don’t need to sleep in total darkness; the intensity of light has to be at a certain level (different levels depending on the spectrum) to suppress melatonin production. That said, complete darkness is probably best. I recommend covering your windows with blackout shades or drapes, or use an eye mask. Also avoid using night-lights, and cover up the display on your clock radio. 
    Keep the temperature in your bedroom below 70 degrees F. A reduction in core body temperature is a part of the sleep-initiation and sleep maintenance process. A room temperature that is too warm or too cool can prevent your core temperature from lowering to its ideal place for good sleep. Aim to keep your bedroom temperature between 60 to 68 degrees, and identify the best room temperature for you through trial and error. 
    Take a hot bath or shower 30 minutes before bedtime. The hot bath increases your core body temperature, opening up the blood vessels in your limbs. When you get out of the bath, heat can leave your body easily (if the room temperature is cool), abruptly dropping your core body temperature, making you drowsy and ready for great sleep. 
    Check your bedroom for electro-magnetic fields (EMFs). These can disrupt your pineal gland and the production of melatonin and serotonin, and may have other negative effects as well. To do this, you need a gauss meter. You can find various models online, starting around $50 to $200. Some experts even recommend pulling your circuit breaker before bed to shut down all power in your house. 
    Move electrical devices away from your bed. If electrical alarm clocks or other gadgets must be used, keep them as far away from your bed as possible, preferably at least three feet. Cell phones, cordless phones, and their charging stations should ideally be kept three rooms away from your bedroom to prevent exposure to harmful and sleep-disrupting electromagnetic fields (EMFs). 
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Brain health. By Dr. Mercola Recent studies show poor sleeping habits cause both brain damage and brain shrinkage, and may even accelerate onset of Alzheimer’s disease. Previous research published in the journal Science revealed that your br…

Weight loss meal plans for diabetic women

What is a Diabetes Meal Plan? 
 
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A diabetes meal plan is a guide that tells you how much and what kinds of food you can choose to eat at meals and snack times. A good meal plan should fit in with your schedule and eating habits. 
Some meal planning tools include: 
<ul>
<li>The plate method</li>


<li>Carb counting</li>


<li>Glycemic index.</li>
</ul>
 
The right meal plan will help you improve your blood glucose, blood pressure, and cholesterol numbers and also help keep your weight on track. 
 
People with diabetes have to take extra care to make sure that their food is balanced with insulin and oral medications (if they take them), and exercise to help manage their blood glucose levels. 
 
This might sound like a lot of work, but your doctor and/or dietitian can help you create a meal plan that is best for you. When you make healthy food choices, you will improve your overall health and you can even prevent complications such as heart disease and some cancers. 
 
There are many ways to help you follow your diabetes meal plan. Some ways are Creating your Plate or Carbohydrate Counting. These two meal planning methods are different but hopefully one is right for you. 
 
What is a Healthy Diet? 
A healthy diet is a way of eating that that reduces risk for complications such as heart disease and stroke. 
 
Healthy eating includes eating a wide variety of foods including: 
 
<ul>
<li>vegetables</li>


<li>whole grains</li>


<li>fruits</li>


<li>non-fat dairy products</li>


<li>beans</li>


<li>lean meats</li>


<li>poultry</li>


<li>fish</li>
</ul>
 
There is no one perfect food so including a variety of different foods and watching portion sizes is key to a healthy diet. Also, make sure your choices from each food group provide the highest quality nutrients you can find. In other words, pick foods rich in vitamins, minerals and fiber over those that are processed. 
 
People with diabetes can eat the same foods the family enjoys. Everyone benefits from healthy eating so the whole family can take part in healthy eating. It takes some planning but you can fit your favorite foods into your meal plan and still manage your blood glucose, blood pressure and cholesterol. 
 
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What is a Diabetes Meal Plan? A diabetes meal plan is a guide that tells you how much and what kinds of food you can choose to eat at meals and snack times. A good meal plan should fit in with your schedule and eating habits. Some meal planning tool…

3 Ways to Improve Your Eye Sight

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<tr><td class="tr-caption" style="text-align: center;">Eye health.</td></tr>
</tbody></table>
3 Ways to Improve Your Eyesight: 
 
1. Eat Right 
Vitamins A, C, E, and minerals like copper and zinc are essential to eyesight. Antioxidants protect your macula from sun damage, and foods rich in sulfur, cysteine, and lecithin help protect the lens of your eye from cataract formation. The omega-3 fat DHA provides structural support to cell membranes that boost eye health. 
 
2. Limit Environmental Toxins 
External factors that contribute to eye damage include fluorescent lights, computer screens, environmental allergens, and chlorine in swimming pools. 
 
3. Sleep 
Getting enough sleep is essential for eye health. Sleep time allows your eyes to fully rest, repair, and recover. 
 
To see the rest of their tips. 
 
Your eyes are your window to the world, and it's easy to take that "window" for granted until your vision begins to fail you. It's important that you realize now that failing vision is not an inevitable part of aging, though it is a common "side effect" of our modern lifestyles. 
For instance, obesity and diabetes are at epidemic proportions right now, and both can impact your eyesight. 
 
Similarly, if you smoke or spend a lot of time in front of the computer, this too can take a toll on your vision health. What do all of these risk factors have in common? They're all lifestyle related. And as the Yahoo Health article above also noted, it's often primarily lifestyle basics that can impact your vision. So along with eating right, limiting environmental toxins and sleeping, as Yahoo suggested, what else can you do to maintain healthy vision? 
 
Most Powerful Antioxidants for Your Eyes 
 
The job of an antioxidant compound is to neutralize dangerous free radicals in your body, including your eyes. Certain antioxidants have been shown to be of particular benefit to your eyes, and those most often talked about are: 
<ul>
<li>Lutein</li>
<li>Zeaxanthin</li>
</ul>
Both of these nutrients, found in eggs, spinach, and other leafy green vegetables, may significantly reduce your risk of age-related macular degeneration, a leading cause of blindness. So I recommend making it a point to include these foods, in their raw, undamaged form, in your diet. 
 
New Nutrient to Help Protect Your Vision 
 
Dr. Mark Tso of the Wilmer Eye Institute at Johns Hopkins University has aptly demonstrated that astaxanthin easily crosses into the tissues of the eye and exerts its effects safely and with more potency than any of the other carotenoids, without adverse reactions. 
 
Specifically, Tso determined astaxanthin could help ameliorate or prevent light-induced damage, photoreceptor cell damage, ganglion cell damage, and damage to the neurons of the inner retinal layers. Other researchers (Shimidzu et al, Bagchi, Martin et al, and Beutner) have since confirmed Dr. Tso's finding that astaxanthin is the most powerful antioxidant ever discovered for eye health, giving your eyes an additional layer of long-term protection. 
 
For example, eye fatigue, eyestrain, blurring and diplopia (aka "double vision," caused by unequal action of your eye muscles) are problems for many people today who work in front of computer displays for long periods of time. Research shows astaxanthin may be beneficial for such issues: 
 
A 2002 Japanese study by Nagaki set out to examine the effects, if any, of astaxanthin on these types of visual problems among computer workers. They found that giving these workers just 5 mg of astaxanthin daily for four weeks resulted in a 46 percent reduction in eyestrain and improved eye focusing. 
 
Another Japanese study by Nakamura in 2004 found similarly positive effects on eyestrain at doses of 4 mg, and even better effects at 12 mg. In fact, there are now NINE different human clinical astaxanthin studies published in the area of eye fatigue, all showing positive results. 
 
Lifestyle Basics for Healthy Eyes 
 
Protecting your eyesight as you age involves many of the same commonsense strategies that will help you prevent chronic disease of all kinds. This includes: 
 
Care for your cardiovascular system. High blood pressure can cause damage to the miniscule blood vessels on your retina, obstructing free blood flow. 
 
One of the primary ways to maintain optimal blood pressure is to avoid fructose. Research by Dr. Richard Johnson, chief of the division of kidney disease and hypertension at the University of Colorado, shows that consuming 74 grams or more per day of fructose (equal to 2.5 sugary drinks) increases your risk of having blood pressure levels of 160/100 mmHg by 77 percent! 
 
Normalize your blood sugar. Excessive sugar in your blood can pull fluid from the lens of your eye, affecting your ability to focus. And, it can damage the blood vessels in your retina, also obstructing blood flow. To keep your blood sugar in a healthy range, follow my comprehensive nutrition guidelines, exercise and avoid excess sugar, especially fructose. 
 
Eat plenty of fresh dark green leafy vegetables, especially kale. Studies have shown that a diet rich in dark leafy greens helps support eye health, and those with the highest consumption of carotenoid-rich vegetables, especially ones rich in lutein and zeaxanthin, had increased vision health. 
 
 Get plenty of healthy animal-based omega-3 fat. A study published in the August 2001 issue of Archives of Ophthalmology found that consuming animal-based omega-3 fatty acids was protective of your healthy vision. Unfortunately, due to widespread pollution and fish farming, fish is no longer an ideal source for omega-3 fats unless you can verify its purity. My favorite alternative is krill oil. 
 
Avoid trans fats. A diet high in trans fat appears to contribute to macular degeneration by interfering with omega-3 fats in your body. Trans fat is found in many processed foods and baked goods, including margarine, shortening, fried foods like French fries, fried chicken and doughnuts, cookies, pastries and crackers. 
 
Avoid aspartame. Vision problems are one of the many potential acute symptoms of aspartame poisoning. 
Quit smoking. Smoking increases free radical production throughout your body, and puts you at risk for less-than-optimal health in many ways, including the risk of decreased vision. 
 
Relaxing Your Mind and Your Eyes Also Crucial to Optimal Vision 
 
Interestingly, your mind may have a significant impact on how well you can see. Research by Harvard University psychologist Ellen Langer and colleagues found that when people were primed to believe they had excellent eyesight, their vision improved.  Likewise, when participants were told their eyesight would improve with practice, it did. The same occurred when people adopted a "try and you will succeed" mindset -- they tried, and their vision successfully improved. 
 
Your thoughts can influence how well you see in part because your mind is the source of much of the stress from outside sources brought to bear upon your eyes. 
 
Every thought of effort in your mind, of whatever sort, transmits a motor impulse to your eye, and every such impulse causes a deviation from the normal in the shape of your eyeball and lessens your foveal sensitivity. 
 
Therefore, if you want to have ideal vision you must minimize stress in your mind. Mental strain of any kind always produces conscious or unconscious eyestrain and if the strain takes the form of an effort to see, an error of refraction is always produced. So while you cannot "make" yourself see, by learning to control your thoughts you can accomplish that end indirectly. 
 
How Relaxation Helps You See 
 
When a disturbing thought is replaced by one that relaxes, your squint disappears, the double vision and the errors of refraction are corrected and this is as true of abnormalities of long standing as of those produced voluntarily. In a fraction of a second the highest degrees of refractive error may be corrected, a squint may disappear, or the blindness of amblyopia may be relieved. If the relaxation is only momentary, the correction is momentary. When it becomes permanent, the correction is permanent. 
 
This relaxation cannot, however, be obtained by any sort of effort. It is fundamental that you understand this; for so long as you think, consciously or unconsciously, that relief from strain may be obtained by another strain your improvement will be delayed. 
 
That is why RELAXING your eyes and addressing the stressors that contribute to the stress are the keys to help you recover your vision. You can read more about this system to restore your vision naturally, which I personally used successfully to regain my own vision without the use of glasses or contacts, here. 
 
The program noted above takes time and dedication, but you can combine it with the Eyeport System -- a patented, clinically proven, and FDA-cleared vision training system, which helps improve your vision fitness and relieve your visual stress in a far shorter time, about 10 minutes a day. Now, this is not a quick fix if you have a serious visual dysfunction, but it is a pretty amazing solution for relieving daily eye stress. Remember, though, you should always check with your vision specialist prior to any vision therapy. 
 
Temporary conditions may contribute to the strain to see that result in poor eyesight, but its foundation lies in wrong habits of thought. 
 
Very seldom is the impairment or destruction of vision due to any fault in the construction of your eye. Of two equally good pairs of eyes, one will retain perfect sight to the end of life, and the other will lose it in kindergarten simply because one looks at things without effort and the other does not. 
 
So in addition to improving the nutrients and antioxidants your central nervous system and eye receive by focusing on high-quality nutrition, as discussed above, you can also support eyesight by optimizing blood flow through relaxation and controlling your thoughts. Mental strain may produce many different kinds of eyestrain, but there is only one solution for all of them, namely, relaxation. 
 
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Eye health. 3 Ways to Improve Your Eyesight: 1. Eat Right Vitamins A, C, E, and minerals like copper and zinc are essential to eyesight. Antioxidants protect your macula from sun damage, and foods rich in sulfur, cysteine, and lecithin help protect …

Eye health

How to Maintain Good Eye Health 
Don't take your eyes for granted. Protect your sight with these six tips: 
 
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<tr><td class="tr-caption" style="text-align: center;">Eye health.</td></tr>
</tbody></table>
1. Eat for Good Vision 
Protecting your eyes starts with the food on your plate. Nutrients such as omega-3 fatty acids, lutein, zinc, and vitamins C and E might help ward off age-related vision problems such as macular degeneration and cataracts, studies show. Regularly eating these foods can help lead to good eye health: 
Green, leafy vegetables such as spinach, kale, and collards 
Salmon, tuna, and other oily fish 
Eggs, nuts, beans, and other non-meat protein sources 
Oranges and other citrus fruits or juices 
Eating a well-balanced diet also helps you maintain a healthy weight, which makes you less likely to get obesity-related diseases such as type 2 diabetes. Diabetes is the leading cause of blindness in adults. 
 
2. Quit Smoking 
Smoking makes you more likely to get cataracts, optic nerve damage, and macular degeneration. If you've tried to quit smoking before and started smoking again, keep trying. The more times you try to quit smoking, the more likely you are to succeed. 
 
3. Wear Sunglasses 
The right kind of sunglasses will help protect your eyes from the sun's ultraviolet (UV) rays. 
 
Too much UV exposure makes you more likely to get cataracts and macular degeneration. 
 
Choose sunglasses that block 99% to 100% of both UVA and UVB rays. Wraparound lenses help protect your eyes from the side. Polarized lenses reduce glare when driving. 
 
If you wear contact lenses, some offer UV protection. It's still a good idea to wear sunglasses for more protection, though. 
 
4. Use Safety Eyewear 
If you work with hazardous or airborne materials on the job or at home, wear safety glasses or protective goggles every time. 
 
Certain sports such as ice hockey, racquetball, and lacrosse can also lead to eye injury. Wear eye protection (such as helmets with protective face masks or sports goggles with polycarbonate lenses) to shield your eyes. 
 
5. Look Away From the Computer Screen 
 
Staring at a computer screen for too long can cause: 
 
<ul>
<li>Eyestrain</li>
<li>Blurry vision</li>
<li>Trouble focusing at a distance</li>
<li>Dry eyes</li>
<li>Headaches</li>
<li>Neck, back, and shoulder pain</li>
</ul>
 
Taking the following steps to protect your eyes: 
 
<ul>
<li>Make sure your glasses or contact lens prescription is up-to-date and adequate for computer use. </li>
<li>Some people may need glasses to help with contrast, glare, and eye strain when using a computer.</li>
<li>Position your computer so that your eyes are level with the top of the monitor. This allows you to look slightly down at the screen.</li>
<li>Try to avoid glare on your computer from windows and lights. Use an anti-glare screen if needed.</li>
<li>Choose a comfortable, supportive chair. Position it so that your feet are flat on the floor.</li>
<li>If your eyes are dry, blink more.</li>
<li>Every 20 minutes, rest your eyes by looking 20 feet away for 20 seconds. At least every 2 hours, get up and take a 15-minute break.</li>
</ul>
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How to Maintain Good Eye Health Don't take your eyes for granted. Protect your sight with these six tips: Eye health. 1. Eat for Good Vision Protecting your eyes starts with the food on your plate. Nutrients such as omega-3 fatty acids, lutein, zinc…

About Bayer HealthCare

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Regarding Bayer Health-related 
Your Bayer Collection is a global company using primary skills inside fields involving healthcare, agriculture along with high-tech products. Bayer Health-related, any subgroup involving Bayer AG using annual product sales involving EUR 17. 9 thousand (2013), is amongst the world’s leading, revolutionary corporations inside healthcare along with health care goods market and is also situated in Leverkusen, Germany. This company brings together your global activities on the Animal Wellbeing, Purchaser Attention, Health care along with Prescription drugs sections. Bayer HealthCare’s goal would be to discover, build, produce along with marketplace goods that will strengthen man along with dog wellness throughout the world. Bayer Health-related features a global workforce involving 56, 000 workers (Dec 31, 2013) and is also displayed with more than 100 countries. More information can be obtained on world wide web. healthcare. bayer. com. 
 
Forward-Looking Claims 
This kind of launch may possibly comprise forward-looking phrases based on recent presumptions along with prophecies made by Bayer Collection or even subgroup managing. Different acknowledged along with not known risks, uncertainties along with components could lead to material variances between your real potential final results, budget, development or even overall performance on the corporation along with the quotations presented the following. These kinds of components incorporate people discussed with Bayer’s open studies that happen to be on your Bayer web page on world wide web. bayer. com. This company thinks absolutely no legal responsibility at all to help replace these kind of forward-looking phrases or to evolve the crooks to potential functions or even trends. 
 
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Regarding Bayer Health-related Your Bayer Collection is a global company using primary skills inside fields involving healthcare, agriculture along with high-tech products. Bayer Health-related, any subgroup involving Bayer AG using annual product s…

Weight loss camps

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What you need to do with weight problems immediately come to the gym and doing fitness exercise on a regular basis every day at least 1 hour per day on the guarantee no change in the first 1 month, weight loss camps, fat loss diets for women, weight loss in women, <a href="http://healthspecialty.blogspot.com/2014/08/weight-loss-programs.html" rel="nofollow" target="_blank">women lose fat</a>, weight loss bod, 
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Lose weight for women was the desire of all women, weight loss camps, fat loss diets for women, weight loss in women, women lose fat, weight loss bod, why women feel inferior if membpunyai excessive weight problems, because in the eyes of the couple…

Bayer health care

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 Health specialty– Data presented at the European Respiratory Society (ERS) Congress today confirm the safety profile and the sustained efficacy of Adempas® (riociguat) over at least two years of treatment in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) or persistent or recurrent CTEPH after surgical treatment, and in patients with pulmonary arterial hypertension (PAH). 
 
Riociguat is a soluble guanylate cyclase (sGC) stimulator, the first member of a novel class of compounds to target a key molecular mechanism underlying pulmonary hypertension (PH). The two-year results of the open-label extension studies CHEST-2 and PATENT-2 confirm that the improvements in exercise capacity and WHO Functional Class (FC) as observed in the pivotal Phase III studies CHEST-1 and PATENT-1 were sustained. Exercise capacity as measured by the Six-Minute Walk Test is a marker of disease severity and a predictor of survival in patients suffering from PH. 
 
The longer observation time in CHEST-2 and PATENT-2 of at least two years allowed for an analysis of the correlation between efficacy endpoints and survival and clinical worsening, via a Cox proportional-hazards regression model. The model demonstrated a significant correlation between baseline values and change from baseline in 6 Minute Walking Distance (6MWD), N-terminal of the prohormone brain natriuretic peptide (NT-proBNP), WHO FC and event-free survival (no clinical worsening). 
 
“The long-term results of these studies are very encouraging, as they substantiate that the improvements PAH or CTEPH patients experience with riociguat are sustainable over the long-term,” said Pisana Ferrari from the European Pulmonary Hypertension Association. “For patients, this means improvements in their ability to walk farther, helping the heart and lungs work better, and making breathing easier when performing everyday basic tasks, and this ultimately suggests improved outcomes and prognoses.” 
 
The analysis of the CHEST-2 data cut-off showed that, at two years, mean exercise capacity of CTEPH patients as measured by the 6MWD had increased by 50m compared to CHEST-1 trial baseline. Moreover, WHO FC had improved or stabilized in 97% of CTEPH patients (39% improved and 58% stabilized). The survival rate of patients at two years of treatment with riociguat was 93%. 
 
In PATENT-2, PAH patients treated with riociguat over two years showed a mean improvement in 6MWD of 47m compared with PATENT-1 trial baseline. WHO FC had improved or stabilized in 91% of PAH patients (33% improved and 58% stabilized). As in CHEST-2, in PATENT-2 the survival rate of patients at two years of treatment with riociguat was 93%. 
 
Riociguat was generally well-tolerated, with a good safety profile. The most commonly reported adverse reaction, occurring in greater than or equal to 10 percent of patients under riociguat treatment (up to 2.5 mg TID), was dizziness. Other adverse reactions included dyspepsia, headache and hypotension. 
 
“The positive results of CHEST-2 and PATENT-2 contribute to the growing evidence of riociguat as an effective and well-tolerated long-term treatment for two of the five types of pulmonary hypertension, having demonstrated in clinical trials early, significant and sustained benefits for patients,” said Principal Investigator Professor Ardeschir Ghofrani, University Hospital Giessen and Marburg, and Kerckhoff Heart and Lung Center, Bad Nauheim, Germany. “The correlation between patient-relevant parameters, such as 6MWD and WHO FC and event-free survival, underlines that close monitoring of patient’s symptoms and exercise capacity is important for predicting outcome and response to treatment.” 
 
Notes to Editors 
 
- Abstract: Riociguat for the treatment of chronic thromboembolic pulmonary hypertension (CTEPH): 2-year results from the CHEST-2 long-term extension 
Session: 216 
Date and time: Monday 8 September, 08.30 – 10.30 am 
Room: A1-4 
 
- Abstract: Riociguat for the treatment of pulmonary arterial hypertension (PAH): 2-year results from the PATENT-2 long-term extension 
Session: 216 
Date and time: Monday 8 September, 08.30 – 10.30 am 
Room: A1-4 
 
About Pulmonary Hypertension 
Pulmonary hypertension (PH) is a severe, progressive, life-changing and life-threatening disorder of the heart and lungs in which the blood pressure in the pulmonary arteries is above normal, and which can lead to heart failure and death. Patients with PH develop a markedly decreased exercise capacity and a reduced quality of life. The most common symptoms of PH include shortness of breath, fatigue, dizziness and fainting, all of which are worsened by exertion. As the symptoms of PH are non-specific, diagnosis can be delayed by as much as two years. Early diagnosis and accurate identification of the PH type are essential, as a delay in treatment initiation can have a negative impact on survival. Continuous treatment monitoring is then vital to ensure that patients are receiving optimal care for their particular type and stage of disease. 
 
There are five different types of PH; each can affect the patient in a different way and every patient may have a different etiology of PH. For the best chance of success patients need to be treated at a PH specialist center. 
 
About Riociguat 
Riociguat is a soluble guanylate cyclase (sGC) stimulator, the first member of a novel class of compounds, discovered and developed by Bayer as an oral treatment to target a key molecular mechanism underlying PH. Riociguat is being investigated as a new and specific approach to treat different types of PH. sGC is an enzyme found in the cardiopulmonary system and the receptor for nitric oxide (NO). When NO binds to sGC, the enzyme enhances synthesis of the signaling molecule cyclic guanosine monophosphate (cGMP). cGMP plays an important role in regulating vascular tone, proliferation, fibrosis, and inflammation. 
 
PH is associated with endothelial dysfunction, impaired synthesis of NO and insufficient stimulation of sGC. Riociguat has a novel mode of action – it sensitizes sGC to endogenous NO by stabilizing the NO-sGC binding. Riociguat also directly stimulates sGC via a different binding site, independently of NO. Riociguat, as a stimulator of sGC, addresses the issue of NO deficiency by restoring the NO-sGC-cGMP pathway, leading to increased generation of cGMP. 
 
With its novel mode of action, riociguat has the potential to overcome a number of limitations of currently approved PAH therapies, including nitric oxide (NO) dependence, and is the first drug which has shown clinical benefits in patients with inoperable CTEPH, or persistent or recurrent CTEPH after surgical treatment, where until the approval of riociguat no pharmacological treatment was available. 
 
The riociguat development program across different forms of PH demonstrates Bayer’s ongoing commitment to understanding this severe and life-threatening condition, with high unmet medical need, to improve the lives of people with PH. 
 
Riociguat was approved under the name Adempas® in the US for use in CTEPH and PAH in October 2013. In Canada, the approvals for CTEPH and PAH followed in September 2013 and March 2014 respectively. In Switzerland and Japan, riociguat was approved in the CTEPH indication in November 2013, and in January 2014 respectively. 
In the EU and US, riociguat has been granted orphan drug designation and was approved by the European Medicines Agency (EMA) under the name Adempas® for use in CTEPH and PAH in March 2014.
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Health specialty– Data presented at the European Respiratory Society (ERS) Congress today confirm the safety profile and the sustained efficacy of Adempas® (riociguat) over at least two years of treatment in patients with inoperable chronic thrombo…

The best weight loss diet for all ages

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<tr><td class="tr-caption" style="text-align: center;">Weight loss diet.</td></tr>
</tbody></table>
"Beauty is based on this Eye on the Beholder "- This specific facts are in fact legitimate. We all wish to meet others conception concerning you. The actual culture sits a lot of emphasis on getting svelte in addition to slim. All knowingly or even unconsciously, participates this corporate jungle associated with weight loss. Regardless of whether you want to slim down to hobby some sort of slim amount or to end up being in good physical shape, the bottom line is that you desire to forfeit weight. 
 
Everyone understands that we now have in essence a pair of methods for weight loss. To begin with, through following rigorous weight eating habits in addition to second of all, through training. Many people would choose the ex - just one. Nevertheless after a weight reduction eating plan routine seriously isn't some sort of make a difference associated with scam. Plenty of willpower, grit and definately will strength are participating even though dieting. Think about, because you rob on your own via scrumptious food, your very best self close friend gorges on the favourite pasta in addition to People from france fried potatoes. Very Painful, Right? 
 
This can be a main reason some shed willpower and give way up the concept of dieting. Dieting could be a painful thumbs otherwise implemented adequately. Many people complain that will despite of the fact that these people stick to a remarkably strenuous in addition to rigorous diet plan, still these people discover zero seen change into their overall look. What they must know will be that will not really each and every diet plan performs in our own bodies. You have to recognise that will each and every body type differs from the others in the other. The key is usually to choose a suitable eating habits which will contain the ideal effects on the system. 
 
There are many weight loss diet doing the rounds, the idea is to decide on the best weight loss diet that triggers the maximum weight loss. GM diet is one of the most popular weight loss diets all over the world. The weight loss diet that was initially formulated for the workers of the General Motors is now known as one of the best weight loss diets in the world. This weight loss diet was formulated in accordance with U.S. Department of Agriculture and the Food and Drug Administration.GM diet is known to have the best diet tips that triggers weight loss. 
 
GM weight loss diet can be followed for as long as desired. However, at a stretch this diet needs to be followed foe seven days. A set of diet tips have been assigned for of these seven days. 
 
Day One: The diet tip is that all fruits can be consumed apart from banana ( due to its high calorie content) 
 
Day Two: The diet tip for day two is all vegetables in as much quantity as desired as long as it is boiled or cooked in minimum oil. 
 
Day Three: The diet tip for the third day is consuming a mixture of vegetables and fruits. There is no limit on the quantity, one can have just as much he wants 
 
Day Four: The diet tip for the fourth day is surviving on only milk and banana. No other food source is allowed on this day. 
 
Day Five: The diet tip for this day is indulgence. One gets to feast on beef and tomato. Just as you had abstained yourself from beef for the past 4 days, you get to eat your heart out. 
 
Day Six: The diet tip for this day is purely beef and vegetables. Eat as much as you want. 
 
Day Seven: The diet tip for the last day that accelerates weight loss is eating brown rice , vegetables and fruit juices. 
 
Experts claim that following the above seven simple diet tips helps in weight loss. This fact makes GM diet one of the most sought after diets. 
 
When we are talking about GM weight loss diet, our talks will remain incomplete without mentioning their Wonder Soup. The soup made with nutritious vegetables like tomato, onion, pepper, cabbage, celery and so on is not only nutritious but also aids in weight loss. The best part about this soup is that it keeps your stomach filled up for a long duration of time. 
 
The best way to choose a weight loss diet to ensure weight loss is by consulting a dietician. Only a dietician has the ability to understand your body's need and requirements and suggest you the best weight loss diet that helps in weight loss.
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Weight loss diet. "Beauty is based on this Eye on the Beholder "- This specific facts are in fact legitimate. We all wish to meet others conception concerning you. The actual culture sits a lot of emphasis on getting svelte in addition to slim. All …